Journal Article
QTL clustering as a mechanism for rapid multi-trait evolution
Yoshizawa, M., O’Quin, K.E., and Jeffery, W.R.
Record Number:
4058
Year:
2013
Journal:
Communicative and Integrative Biology
Volume:
6(4): e24548
Abstract:
Cave-dwelling animals exhibit remarkable convergence in multiple cave-related traits, yet the genetic mechanisms responsible for the evolution and integration of many such traits remain unclear. Astyanax mexicanus is a model cave-dwelling fish with sighted surface-dwelling (surface fish) and blind cave-dwelling (cavefish) forms. Using a genetic cross between these morphs, we discovered significant correlations among several cave-related traits, including reduced eyes, increased superficial neuromast receptors located within the eye orbit (EO SN) and a vibration-attraction behavior (VAB) that facilitates foraging in darkness. Furthermore, we discovered that the quantitative trait loci (QTL) underlying these traits are clustered within the Astyanax genome. Following an ablation experiment that demonstrated that the EO SN contribute to VAB, we concluded that the adaptive evolution of VAB and EO SN has likely contributed to eye loss in cavefish. In this addendum, we further discuss the possible role of multi-trait QTL clustering in facilitating rapid adaptation.
Keywords: cavefish, evolution, adaptation, lateral line, quantitative trait locus, QTL cluster, pleiotrop
Times Cited:
1
Relevent Species: