Journal Article
The eye as an organizer of craniofacial development
Kish, P.E., Bohnsack, B.L., Gallina, D., Kasprick, D.S. and Kahana, A.
Record Number:
4144
Year:
2011
Journal:
Genesis
Pages:
222-230
Volume:
49
Abstract:
Summary: The formation and invagination of the optic
stalk coincides with the migration of cranial neural
crest (CNC) cells, and a growing body of data reveals
that the optic stalk and CNC cells communicate to lay
the foundations for periocular and craniofacial development.
Following migration, the interaction between the
developing eye and surrounding periocular mesenchyme
(POM) continues, leading to induction of transcriptional
regulatory cascades that regulate craniofacial
morphogenesis. Studies in chick, mice, and zebrafish
have revealed a remarkable level of genetic and
mechanistic conservation, affirming the power of each
animal model to shed light on the broader morphogenic
process. This review will focus on the role of the developing
eye in orchestrating craniofacial morphogenesis,
utilizing morphogenic gradients, paracrine signaling,
and transcriptional regulatory cascades to establish an
evolutionarily-conserved facial architecture. We propose
that in addition to the forebrain, the eye functions
during early craniofacial morphogenesis as a key organizer
of facial development, independent of its role in
vision.
Times Cited:
6
Relevent Species: