Journal Article
Towards deciphering variations of heart regeneration in fish
Jazwinska, A. and Blanchoud, S.
Record Number:
4491
Year:
2019
Journal:
Current Opinion in Physiology
Abstract:
Among adult vertebrates, the zebrafish presents the rather exceptional capacity to efficiently
regenerate its heart after injury. This bony fish has thus become a leading genetic model organism to
elucidate the natural mechanisms of successful cardiac restoration. Given its potential biomedical
significance, parallel analyses between zebrafish and mammals are aiming at the identification of the
permissive and restrictive factors modulating the underlying cardiomyocyte proliferation. The recent
discovery that some other bony fish species have a lower regenerative competence than zebrafish
opens new opportunities for comparative studies within a framework of similar animal physiology
and organ structure. Here, we review recently identified modulators of cardiomyocyte proliferation
in zebrafish and highlight the results obtained by this comparative approach.
Keywords: zebrafish, medaka, cavefish, teleost, cardiac regeneration, cardiomyocyte proliferation,
cardiomyocyte polyploidy, preconditioning, inter-species analyses
Times Cited:
1
Relevent Species: