Journal Article
Molecular evolution and characterization of fish stathmin genes
Cao, J. and Cheng, X.
Record Number:
4808
Year:
2020
Journal:
Animals
Pages:
1-12
Volume:
10,1328
URL:
www.mdpi.com/journal/animals
Abstract:
Simple Summary: Stathmin is a highly conserved microtubule remodeling protein. Here, 175 putative
stathmin genes were identified in 27 species of fish. Gene organization, motif distribution, divergence
of duplicated genes, functional divergence, synteny relationship, and protein-protein interaction
were performed to investigate their evolutionary history. In addition, expression profiles of some
stathmins were examined under dimethoate treatment. The results will provide useful references for
further functional analyses.
Abstract: Stathmin is a highly conserved microtubule remodeling protein, involved in many
biological processes such as signal transduction, cell proliferation, neurogenesis and so on. However,
little evolutional information has been reported about this gene family in fish. In this study, 175 stathmin
genes were identified in 27 species of fish. Conserved exon-intron structure and motif distributions
were found in each group. Divergence of duplicated genes implied the species’ adaptation to the
environment. Functional divergence suggested that the evolution of stathmin is mainly influenced
by purifying selection, and some residues may undergo positive selection. Moreover, synteny
relationship near the stathmin locus was relatively conserved in some fish. Network analyses also
exhibited 74 interactions, implying functional diversity. The expression pattern of some stathmin
genes was also investigated under pesticide stress. These will provide useful references for their
functional research in the future.
Keywords: stathmin; molecular evolution; functional divergence; neurotoxicity
Times Cited:
1
Relevent Species: