Journal Article
Author Correction: Insulin resistance in cavefish as an adaptation to a nutrient-limited environment
Riddle, M.R., Aspiras, A.C., Gaudenz, K., Peuß, R., Sung, J.Y., Martineau, B., Peavey, M., Box, A.C., Tabin, J.A., McGaugh, S., Borowsky, R., Tabin, C.J. and Rohner, N.
Record Number:
5014
Year:
2020
Journal:
Nature
Notes:
Correction to: Nature https://doi.org/10.1038/nature26136
Published online 21 March 2018
Abstract:
Cave-adapted populations of the Mexican tetra, Astyanax mexicanus,
have dysregulated blood glucose homeostasis and are insulin-resistant
compared to river-adapted (‘surface’) populations. We found that multiple
cave populations, including those inhabiting the Tinaja and Pachón
caves, carry a mutation in the insulin receptor that leads to decreased
insulin binding in vitro and contributes to hyperglycaemia. As part
of the analysis that led to this conclusion, we measured fasting blood
glucose levels in F2 fish derived from a cross between a surface fish
homozygous for the ancestral insulin receptor allele and a cavefish
homozygous for the derived allele, allowing us to correlate inheritance
of the mutation with inheritance of glucose dysregulation. In
this Article, we inadvertently indicated that the cavefish grandparent
used in this cross was descended from the Tinaja population. However,
subsequent analysis has definitively indicated that this individual actually
belongs to the Pachón population. However, as both the Tinaja
and Pachón populations carry the same P211L mutation in the insulin
receptor, the logic of the experiment, the genotype–phenotype correlation
we observed, and the conclusions of the study remain unchanged.
Everything in the manuscript is still accurate, other than the name of
the cave in the second and third paragraphs on page 649 of the PDF
version of the original Article and in Fig. 3b and its legend. This error
has not been corrected online.
Times Cited:
1
Relevent Species: