Journal Article
Social-like responses are inducible in asocial Mexican cavefish despite the exhibition of strong repetitive behaviour
Iwashita, M. and Yoshizawa, M.
Record Number:
5412
Year:
2021
Journal:
bioRxiv preprint
Volume:
258640
Notes:
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Now published in elife
Abstract:
Social behaviour is a hallmark of complex animal systems; however, some species appear to have secondarily lost this social ability. In these non-social species, whether social abilities are permanently lost or suppressed is unclear. The blind cavefish Astyanax mexicanus is known to be asocial. Here, we reveal that cavefish exhibited social-like interactions in familiar environments but suppressed these interactions in stress-associated unfamiliar environments. Furthermore, the level of suppression in sociality was positively correlated with that of stereotypic repetitive behaviour, as seen in mammals. Treatment with a human antipsychotic drug targeting the dopaminergic system induced social-like interactions in cavefish, even in unfamiliar environments, while reducing repetitive behaviour. Overall, these results suggest that the antagonistic relationship between repetitive and social-like behaviours is deeply shared from teleosts through mammals.
Times Cited:
1
Relevent Species: