Journal Article
Evolution of central neural circuits: state of the art and perspectives
Roberts, R.J.B., Pop, S. and Prieto-Godino, L.L.
Record Number:
6010
Year:
2022
Journal:
Nature Reviews Neuroscience
Pages:
yy
Volume:
xx
Notes:
Supplementary information The online version contains supplementary material available at
https://doi.org/10.1038/s41583-022-00644-y
Abstract:
The wide variety of animal behaviours that can be observed today arose
through the evolution of their underlying neural circuits. Advances in
understanding the mechanisms through which neural circuits change
over evolutionary timescales have lagged behind our knowledge of
circuit function and development. This is particularly true for central
neural circuits, which are experimentally less accessible than peripheral
circuit elements. However, recent technological developments —
including cross-species genetic modifications, connectomics and
transcriptomics — have facilitated comparative neuroscience studies
with a mechanistic outlook. These advances enable knowledge from
two classically separate disciplines — neuroscience and evolutionary
biology — to merge, accelerating our understanding of the principles
of neural circuit evolution. Here we synthesize progress on this
topic, focusing on three aspects of neural circuits that change over
evolutionary time: synaptic connectivity, neuromodulation and
neurons. By drawing examples from a wide variety of animal phyla,
we reveal emerging principles of neural circuit evolution
Times Cited:
1
Relevent Species: