Journal Article
From darkness to discovery: evolutionary, adaptive, and translational genetic insights from cavefish
Swaminathan, A., Xia, F. and Rohner, N.
Record Number:
6493
Year:
2024
Journal:
Trends in Genetics
Pages:
24-38
Volume:
40
Abstract:
How genotype determines phenotype is a well-explored question, but genotype–
environment interactions and their heritable impact on phenotype over the
course of evolution are not as thoroughly investigated. The fish Astyanax
mexicanus, comprising surface and cave ecotypes, is an ideal emerging model
to study the genetic basis of adaptation to new environments. This model has
permitted quantitative trait locus (QTL) mapping and whole-genome comparisons
to identify the genetic bases of traits such as albinism and insulin resistance and
has helped in the better understanding of fundamental evolutionary mechanisms.
In this review, we summarize recent advances in A. mexicanus genetics and discuss
its broader impact on the fields of adaptation and evolutionary genetics.
Times Cited:
1
Relevent Species: