Conference Proceedings
Temperature-independent telomere lengthening with age in the long-lived human fish (Proteus anguinus)
Guillaume O., Voituron Y., Dumet, A., Zahn, S. and Criscuolo, F.
Record Number:
6929
Year:
2024
Abstract:
Generally, in the absence of active enzymatic repair by telomerase, telomere ends universally and inevitably erode over time in the adult soma, with however a strong effect of the thermal history of the individual. We investigated the age-related changes in relative telomere length in the skin of the cave dweller Proteus anguinus who lives naturally in a stable thermal environment over its entire long life (possibly up to 80 years), allowing comparison with other homeothermic animals like birds and mammals. Data showed a positive relation between telomere length and individual age, independent of sex and body size. A segmented analysis highlighted a breakpoint in the telomere length–age relationship, suggesting that telomere length reached a plateau at the age of 25 years.
Further studies are engaged to investigate whether the telomere really lengthens thorough the life or individuals with longer telomere get a selective advantage
Times Cited:
1
Conference Name:
26th International Conference on Subterranean Biology and 6th International Symposium on Anchialine Ecosystems: Cagliari 9-14 Sept 2024
Relevent Species: