Journal Article
Divergent 3D genome organization links to metabolic adaptation in cavefish
Biswas, T., Li, H. and Rohner, N.
Record Number:
6965
Year:
2025
Journal:
bioRxiv preprint
Abstract:
The cave morphs of Astyanax mexicanus adapt to caves through distinct metabolic and
morphological traits. While changed gene expression is a primary driver of these adaptations, the underlying role of 3D genome organization – a key regulator of gene expression – remains unexplored. We analyzed liver 3D genome architecture in surface and cave morphs and identified cave-specific 3D genome signatures which, when integrated with transcriptomic and epigenetic data, associated with expression changes in genes associated with cave metabolism. In this study, comparing morphs within the same species, we established a foundation for better understanding of how 3D genome may drive phenotypic diversity
Times Cited:
1
Relevent Species: